Preferred Label : Retinoid X Receptor;
NCIt synonyms : RXR; Retinoic Acid Receptor RXR; Nuclear Receptor Subfamily 2 Group B; Retinoid-X Receptor; NR2B;
NCIt definition : Human nuclear Retinoid X Receptors RXRA, RXRB, and RXRG (NR2/RXR Family) are transcriptional
regulators composed of N-terminal modulating domain, DNA-binding domain (AGGTCA response
elements), and C-terminal 9-cis RA-binding domain. RXR homodimers and RXR/RAR heterodimers
mediate distinct retinoic acid response pathways. RXRs also interact with TH- and
vitamin D receptors, and with NCOA3, NCOA6, PML, and PPARG coactivators; and mediate
RA biological effects by binding to specific target gene promoters and inducing target
gene transcription. RXRs/LXRs and RXRs/FXR may mediate cholesterol homeostasis, by
governing cholesterol transport from peripheral cells, inhibiting cholesterol absorption
in the small intestine, and repressing bile acid synthesis through upregulation of
ABC1 and repression of CYP7A1 expression. (NCI);
Origin ID : C17534;
UMLS CUI : C5441771;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_affected_by_chemical_or_drug
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_is_biomarker_type
- gene_product_plays_role_in_biological_process
- is_target
