" /> Alitretinoin - CISMeF





Preferred Label : Alitretinoin;

NCIt synonyms : 9-cis-Retinoic Acid; 9-cRA; Retinoicacid-9-cis; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-trans-4-trans-6-cis-8-trans-nonatetraenoic Acid; 9-cis Retinoic Acid; 9-cis-RA;

NCIt definition : An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities. Alitretinoin binds to and activates nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR); these activated receptors act as transcription factors, regulating gene expression that results in the inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells.;

Alternative definition : NCI-GLOSS: A drug being studied for cancer prevention. It belongs to the family of drugs called retinoids.;

UNII : 1UA8E65KDZ;

InChIKey : SHGAZHPCJJPHSC-ZVCIMWCZSA-N;

CAS number : 5300-03-8;

Drug name : Panretin; Panretyn; Panrexin;

Molecule name : LGD 1057; LGD-1057; ALRT 1057; ALRT-1057;

Chemical formula : C20H28O2;

NSC code : 659772;

ChEBI ID : CHEBI:50648;

Codes from synonyms : NSC0659772; CDR0000045583; 01346; 6008;

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30/05/2025


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