Alitretinoin - CISMeF

Preferred Label : Alitretinoin;

NCIt synonyms : 9-cis-Retinoic Acid; 9-cRA; Retinoicacid-9-cis; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-trans-4-trans-6-cis-8-trans-nonatetraenoic Acid; 9-cis Retinoic Acid; 9-cis-RA;

NCIt definition : An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities. Alitretinoin binds to and activates nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR); these activated receptors act as transcription factors, regulating gene expression that results in the inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells.;

Alternative definition : NCI-GLOSS: A drug being studied for cancer prevention. It belongs to the family of drugs called retinoids.;

UNII : 1UA8E65KDZ;

InChIKey : SHGAZHPCJJPHSC-ZVCIMWCZSA-N;

CAS number : 5300-03-8;

Drug name : Panretin; Panretyn; Panrexin;

Molecule name : LGD 1057; LGD-1057; ALRT 1057; ALRT-1057;

Chemical formula : C20H28O2;

NSC code : 659772;

ChEBI ID : CHEBI:50648;

Codes from synonyms : NSC0659772; CDR0000045583; 01346; 6008;

Details

Origin ID

C1574;

UMLS CUI

C0281666;

Automatic exact mappings (from CISMeF team)
- alitretinoin [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
- Vitamin [UMLS semantic type]
UMLS correspondences (same concept)
- Alitretinoin [MeSH Descriptor]
- Alitretinoin (substance) [SNOMED CT concept]
- Product containing alitretinoin (medicinal product) [SNOMED CT concept]
- alitretinoin [ATC Code]
- alitretinoin [Substance BNPC]
- alitretinoin [ATC Code]
- alitretinoin [MeSH concept]
Validated automatic mappings to BTNT
- alitretinoin [ATC Code]
chemical_or_drug_affects_gene_product
- Retinoic Acid Receptor [NCIt concept]
- Retinoid X Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Retinoic Acid Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Apoptosis [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Positive Regulation of Cell Differentiation [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- 9-cis-Retinoic Acid/Interferon Alfa [NCIt concept]
- 9-cis-Retinoic Acid/Tamoxifen [NCIt concept]
- Carboplatin/9-cis-Retinoic Acid [NCIt concept]
- Topical Alitretinoin Regimen [NCIt concept]

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