NCIt definition : A synthetic analogue of 9-cis retinoic acid with potential antineoplastic and chemopreventive
activities. Retinoid 9cUAB30 binds to and activates retinoid X receptor (RXR) homodimers
and/or and retinoic acid receptor (RAR)/RXR heterodimers, which may result in the
dissociation of corepressor protein and the recruitment of coactivator protein, followed
by transcription of downstream target genes into mRNAs and protein translation. Gene
transcription regulated by these transcription factors may result in inhibition of
cell proliferation, induction of cell differentiation, and apoptosis of both normal
cells and tumor cells.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment and prevention of cancer. It
blocks an enzyme that keeps cells alive by adding material to the ends of chromosomes.
Blocking this enzyme may cause the cancer cells to die. 9cUAB30 is a type of retinoic
acid and a type of telomerase inhibitor.;
UNII : PFP09575EX;
CAS number : 205252-57-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 205252-57-9
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