Preferred Label : Bexarotene;
NCIt synonyms : 3-methyl TTNEB; 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic Acid;
NCIt related terms : LGD1069; Targretin;
NCIt definition : A synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic
and embryotoxic properties. Bexarotene selectively binds to and activates retinoid
X receptors (RXRs), thereby inducing changes in gene expression that lead to cell
differentiation, decreased cell proliferation, apoptosis of some cancer cell types,
and tumor regression. (NCI04);
Alternative definition : NCI-GLOSS: A drug used to treat skin problems caused by cutaneous T-cell lymphoma
that have not gotten better after other treatment. It is also being studied in the
treatment of other types of cancer. Bexarotene is a type of retinoid.;
UNII : A61RXM4375;
InChIKey : NAVMQTYZDKMPEU-UHFFFAOYSA-N;
CAS number : 153559-49-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 153559-49-0
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Drug name : Targretin;
Molecule name : LGD1069;
Chemical formula : C24H28O2;
ChEBI ID : CHEBI:50859;
Codes from synonyms : CDR0000523453; 09151; CDR0000045423; CDR0000044482; 69;
Origin ID : C1635;
UMLS CUI : C0765273;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
