" /> Rexinoid NRX 194204 - CISMeF





Preferred Label : Rexinoid NRX 194204;

NCIt synonyms : Retinoid X Receptor Agonist IRX4204; RXR Agonist IRX4204;

NCIt related terms : VTP-194204; Rexinoid VTP-194204;

NCIt definition : An orally bioavailable synthetic retinoid X receptor (RXR) agonist with potential antineoplastic, neuroprotective, immunoregulatory, and disease-modifying activities. Upon administration, rexinoid VTP-194204 selectively binds to and activates RXRs thereby activating RXR-mediated signaling pathways and inducing changes in gene expression that leads to cell differentiation, decreases cell proliferation, and induces apoptosis in susceptible cancer cells. VTP-194204 enhances the differentiation of CD4-positive T-lymphocytes into inducible regulatory T cells (iTreg) and suppresses the development of inflammatory T helper 17 (Th17) cells. In addition, VTP-194204 is able to cross the blood-brain barrier (BBB) and induces the differentiation of oligodendrocyte precursor cells (OPCs) into oligodendrocytes, promotes repair of myelin, and enhances the survival of dopaminergic neurons.;

UNII : 877M97Z38Y;

CAS number : 220619-73-8;

Molecule name : NRX194204; AGN194204; IRX-4204; VTP-194204; VTP 194204; IRX 4204;

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28/07/2025


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