NCIt definition : An orally bioavailable synthetic retinoid X receptor (RXR) agonist with potential
antineoplastic and anti-inflammatory activities. Rexinoid NRX 194204 selectively binds
to and activates RXRs. Because RXRs can form heterodimers with several nuclear receptors
(NRs), RXR activation by this agent may result in a broad range of gene expression
depending on the effector DNA response elements activated. Rexinoid NRX 194204 may
inhibit the tumor-necrosis factor (TNF)-mediated release of nitric oxide (NO) and
interleukin 6 (IL6) and may inhibit tumor cell proliferation. This agent appears to
be less toxic than RAR-selective ligands.;