NCIt related terms : all-trans-4'-hydroxyretinanilide;
NCIt definition : An orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential
antineoplastic and chemopreventive activities. Fenretinide binds to and activates
retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis
in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis-associated
growth factors and their receptors and exhibits retinoid receptor-independent apoptotic
properties. (NCI04);
Alternative definition : NCI-GLOSS: A substance being studied in the treatment and prevention of some types
of cancer. Fenretinide may cause ceramide (a wax-like substance) to build up in tumor
cells and kill them. It is a type of retinoid, which are substances related to vitamin
A.;
UNII : 187EJ7QEXL;
InChIKey : AKJHMTWEGVYYSE-FXILSDISSA-N;
CAS number : 65646-68-6;
Molecule name : McN-R-1967;
Chemical formula : C26H33NO2;
NSC code : 374551;
ChEBI ID : CHEBI:42588;
Codes from synonyms : CDR0000045233; NSC0374551; 00056;