Chromatin Remodeling Complex and Coactivator Pathway

Preferred Label : Chromatin Remodeling Complex and Coactivator Pathway;

NCIt related terms : Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells;

Alternative definition : BIOCARTA: RXR and RAR are nuclear receptors that bind either all trans retinoic (tRA) or 9cis retinoic acid (9cisRA). In the absence of ligand corepressors with histone deacetylase activity are bound to the RAR/RXR heterodimer and suppress transcription. Once they bind retinoic acid a conformational change in the receptors cause the dissociation of the corepressors and the binding of coactivators with histone acetylase activity. Following ligand binding by the heterodimer the receptors and proteins in the basal transcription machinery (like TBP and TAF135) are degraded by the proteasome. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_rarrxrPathway;

Details

Origin ID

C39216;

UMLS CUI

C1516510;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- AT-Rich Interactive Domain-Containing Protein 1A [NCIt concept]
- DNA-Directed RNA Polymerase II Subunit RPB1 [NCIt concept]
- General Transcription Factor IIE Subunit 1 [NCIt concept]
- General Transcription Factor IIF Subunit 1 [NCIt concept]
- Glucocorticoid Receptor [NCIt concept]
- Histone Acetyltransferase KAT2B [NCIt concept]
- Histone Deacetylase 3 [NCIt concept]
- Nuclear Receptor Coactivator 1 [NCIt concept]
- Nuclear Receptor Coactivator 2 [NCIt concept]
- Nuclear Receptor Coactivator 3 [NCIt concept]
- Nuclear Receptor Corepressor 2 [NCIt concept]
- Retinoic Acid Receptor Alpha [NCIt concept]
- Retinoic Acid Receptor RXR-Alpha [NCIt concept]
- TATA-Box-Binding Protein [NCIt concept]
- TFIIH Basal Transcription Factor Complex Helicase XPB Subunit [NCIt concept]
- Transcription Initiation Factor IIA [NCIt concept]
- Transcription Initiation Factor IIA Alpha Chain [NCIt concept]
- Transcription Initiation Factor IIA Beta Chain [NCIt concept]
- Transcription Initiation Factor IIA Subunit 2 [NCIt concept]
- Transcription Initiation Factor IIB [NCIt concept]
pathway_has_gene_element
- ARID1A wt Allele [NCIt concept]
- ERCC3 wt Allele [NCIt concept]
- GTF2A1 wt Allele [NCIt concept]
- GTF2B wt Allele [NCIt concept]
- GTF2E1 wt Allele [NCIt concept]
- GTF2F1 wt Allele [NCIt concept]
- HDAC3 wt Allele [NCIt concept]
- KAT2B wt Allele [NCIt concept]
- NCOA1 wt Allele [NCIt concept]
- NCOA2 wt Allele [NCIt concept]
- NCOA3 wt Allele [NCIt concept]
- NCOR2 wt Allele [NCIt concept]
- NR3C1 wt Allele [NCIt concept]
- POLR2A wt Allele [NCIt concept]
- RARA wt Allele [NCIt concept]
- RXRA wt Allele [NCIt concept]
- TBP wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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