General Transcription Factor IIE Subunit 1

Preferred Label : General Transcription Factor IIE Subunit 1;

NCIt synonyms : Transcription Initiation Factor IIE Subunit Alpha; Transcription Initiation Factor IIE Alpha Subunit; GTF2E1; General Transcription Factor IIE 56 kDa Subunit; General Transcription Factor IIE1 Alpha 56kDa; TFIIE-Alpha; Transcription Initiation Factor-IIE Alpha Subunit;

NCIt definition : General transcription factor IIE subunit 1 (439 aa, 50 kDa) is encoded by the human GTF2E1 gene. This protein plays a role in both transcriptional initiation and RNA elongation.;

NCIt note : GTF2E1 appears required with GTF2E2 for stable formation of a preinitiation complex and for basal, as well as Sp1-activated, transcription.;

Details

Origin ID

C29677;

UMLS CUI

C0378728;

Currated CISMeF NLP mapping
- TFIIE alpha [MeSH concept]
OMIM relation
- General transcription factor iie, polypeptide 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GTF2E1 protein, human [MeSH Supplementary Concept]
- TFIIE alpha [MeSH concept]
gene_encodes_gene_product
- Basal Transcription Factor Gene [NCIt concept]
- GTF2E1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_is_element_in_pathway
- Chromatin Remodeling Complex and Coactivator Pathway [NCIt concept]
- Estrogen Receptor Regulation by CARM1 Pathway [NCIt concept]
- hSWI-SNF Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcription Initiation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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