NCIt synonyms : General Transcription Factor Gene;
NCIt definition : Human Basal Transcription Factor Genes encode Basal Transcription Factors, a diverse
group of general factors required for transcription of all eukaryotic PolII genes.
Initiation of transcription from eukaryotic protein-coding genes is a complex process
requiring RNA polymerase II (PolII) and a cadre of transcription factors. The general
transcription factors and PolII form a multiprotein complex near the transcription
start site by interacting with core promoter elements. The most common core element
is the TATA box, typically 25-30 bp upstream of the start site.;
Semantic type(s)