Transcription Initiation Factor IIB

Preferred Label : Transcription Initiation Factor IIB;

NCIt synonyms : RNA Polymerase II Transcription Factor IIB; General Transcription Factor TFIIB; GTF2B; General Transcription Factor IIB; S300-II; General Transcription Factor-TFIIB;

NCIt definition : Transcription initiation factor IIB (316 aa, 95 kDa) is encoded by the human GTF2B gene. This protein plays a role in the initiation of RNA polymerase II-mediated gene transcription.;

NCIt note : General Transcription Factor TFIIB plays a central role in assembly of the preinitiation complex, required for transcription initiation by RNA polymerase II. Sequence-specific DNA-binding TFIIB forms the DAB complex with promoter-bound TFIID and TFIIA, bridging TFIID and RNA Polymerase II. TFIIB interacts with the promoter TFIIB-recognition element BRE. BRE suppresses basal transcription by a core promoter, which increases transcription in the presence of an activator that can disrupt promoter-bound TFIIB-BRE.;

Details

Origin ID

C29676;

UMLS CUI

C1333809;

OMIM relation
- General transcription factor iib [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Basal Transcription Factor Gene [NCIt concept]
- GTF2B Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_is_element_in_pathway
- Chromatin Remodeling Complex and Coactivator Pathway [NCIt concept]
- hSWI-SNF Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcription Initiation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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