NCIt definition : Transcription initiation factor TFIID subunit 6 (677 aa, 72 kDa) is encoded by the
human TAF6 gene. This protein is involved in the regulation of transcription by RNA
polymerase II.;
NCIt note : TBP-Associated Factor 6, one of the smaller TFIID subunits, binds tightly to TAF1
(the largest subunit of TFIID) to TBP, and directly to TAFII40. Four isoforms have
been identified; one isoform precludes binding of another TFIID subunit, reducing
transcription and initiating apoptotic signals.;