" /> Transcription Factor IIIB 50 kDa Subunit - CISMeF





Preferred Label : Transcription Factor IIIB 50 kDa Subunit;

NCIt synonyms : BRF2 Subunit of RNA Polymerase III Transcription Initiation Factor; BRF2, Subunit of RNA Polymerase III Transcription Initiation Factor, BRF1-Like; B-Related Factor 2; RNA Polymerase III Transcription Initiation Factor BRF2; TFIIIB50; BRF-2; T hTFIIIB50; hBRFU; Transcription Factor IIB-Related Factor; BRFU; FLJ11052; RNA Polymerase-III Transcription Initiation Factor-BRF2; BRF2;

NCIt definition : Transcription factor IIIB 50 kDa subunit (419 aa, 47 kDa) is encoded by the human BRF2 gene. This protein is involved in the activation of RNA polymerase III-mediated transcription.;

NCIt note : BRF2 is involved in the nucleation of a polymerase III-specific small nuclear RNA (snRNA) transcription initiation complex. BRF2 does not directly bind DNA but it interacts with the TATA-binding protein (TBP), and they then bind cooperatively to the polymerase III promoter region of snRNA. The BRF2 protein has a zinc ribbon domain and a core domain. The TBP/BRF2 complex does not have strict requirements for sequence motifs outside the TATA box. Arg235 and phe250 of TBP, and repeat 2 of the BRF2 core domain, are necessary for complex formation with DNA. BRF2 also forms a stable complex on the TATA box of the polymerase II-specific adenovirus major late promoter. (from OMIM and LocusLink);

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18/05/2024


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