Transcription Factor IIIB 90 kDa Subunit

Preferred Label : Transcription Factor IIIB 90 kDa Subunit;

NCIt synonyms : TATA Box-Binding Protein-Associated Factor, RNA Polymerase III, Subunit 2; TBP-Associated Factor, RNA Polymerase III, 90-kD; GTF3B; Transcription Initiation Factor IIIB; TATA Box-Binding Protein-Associated Factor RNA Polymerase III Subunit 2; GTF3B 90-kD Subunit; BRF1 Homolog; hTFIIIB90; Transcription Factor IIIB 90-kD Subunit; hBRF; TAF3C; BRF1, S. cerevisiae, Homolog of; BRF1; TFIIIB90; TATA Box Binding Protein (TBP)-Associated Factor 3C; TF3B90; B-Related Factor 1; BRF-1; TBP-Associated Factor RNA Polymerase III 90kD; BRF; BRF1 Homolog Subunit of RNA Polymerase III Transcription Initiation Factor IIIB; TAF3B2; Transcription Factor IIIB, 90-kD Subunit; BRF1: BRF1 Homolog, Subunit of RNA Polymerase III Transcription Initiation Factor IIIB (S.cerevisiae); TAFIII90; General Transcription Factor 3B, 90-kD Subunit; General Transcription Factor IIIB 90kD Subunit; General Transcription Factor 3B 90-kD Subunit; TATA Box Binding Protein (TBP)-Associated Factor RNA Polymerase III Subunit 2; GTF3B, 90-kD Subunit;

NCIt definition : Transcription factor IIIB 90 kDa subunit (677 aa, 74 kDa) is encoded by the human BRF1 gene. This protein plays a role in the transcription of both tRNA and snRNA.;

NCIt note : General Transcription Factor 3B 90-kD Subunit functions at different promoters on tRNA, 5S rRNA, and other small RNA genes. Related to GTF2B (N-terminus), GTF3B contains a highly charged region and HMG2-related region. Essential for transcription initiation, GTF3B (C-terminus) binds TBP (collectively, TFIIIB) as one of three RNA polymerase III transcription factor subunits. Following GTF3A or GTF3C recognition of promoter elements, GTF3B and RNA polymerase III bind sequentially.;

Details

Origin ID

C28705;

UMLS CUI

C1096984;

OMIM relation
- Brf1 subunit of rna polymerase III transcription initiation factor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BRF1 protein, human [MeSH Supplementary Concept]
- BRF1 protein, human [MeSH concept]
gene_encodes_gene_product
- BRF1 Gene [NCIt concept]
- Basal Transcription Factor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Protein Complex Subunit [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- RNA Polymerase III Transcription Pathway [NCIt concept]
gene_product_is_physical_part_of
- TFIIIB [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcription Initiation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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