Preferred Label : RNA Polymerase III Transcription Pathway;
NCIt related terms : RNA polymerase III transcription;
Alternative definition : BIOCARTA: Unlike the RNA polymerase II that transcribes a large variety of genes that
encode proteins, RNA polymerase III transcribes only a limited number of genes (i.e.,
5S rRNA, tRNA, 7SL RNA, U6 snRNA, and a few other small stable RNAs); however, the
transcriptional activities of RNA pol III along with pol I account for 80% of total
RNA synthesis. The A and B block sequences found in most pol III promoters are recognized
by a multisubunit complex, TFIIIC. The binding of TFIIIC recruits TFIIIB, a complex
of polypeptides (in human, TATA-binding protein (TBP), TFIIB-related factor (BRF),
and one or more unidentified protein). Once TFIIIB is brought to the general location
by TFIIIC and optimally positioned by TBP, the transcription initiates about 30bp
downstream. The transcription process requires the melting of dsDNA and participation
of TFIIIB. Unlike pol I and II, pol III termination occurs efficiently at four or
more T residues without other protein factors. La protein can stimulate the release
of RNA and pol III transcription; however, deletion of La has no apparent effect on
pol III activity. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_RNApol3Pathway;
Origin ID : C39225;
UMLS CUI : C1514668;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
