Preferred Label : Glucocorticoid Receptor;
NCIt synonyms : Nuclear Receptor Subfamily 3, Group C, Member 1; NR3C1; Glucocorticoid Receptor, Lymphocyte; GR; Nuclear Receptor Subfamily 3 Group C Member 1;
NCIt definition : Glucocorticoid receptor (777 aa, 86 kDa) is encoded by the human NR3C1 gene. This
protein plays a role in both chromatin remodeling and transcriptional regulation.;
NCIt note : Complexed with HSP90, HSP70, and FKBP5 or PPP5C, activated GR is transported (by dynein/FKBP4)
to the nucleus and binds to target GREs as a homodimeric or heterodimeric (NR3C2/RXR)
transcription factor and modulates other transcription factors to regulate blood glucose
concentration, protein/fat metabolism, inflammatory responses, cell proliferation,
and differentiation. GR appears to interact with NRIP1, POU2F1, POU2F2, STAT5A, STAT5B,
SMARCA4, CREBBP/EP300, TADA2L, p160, NCOA2, and NCOA6. Sumoylation and BAG1 interaction
inhibits transactivation.;
Origin ID : C17071;
UMLS CUI : C1370369;
Currated CISMeF NLP mapping
- False automatic mappings
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
- is_target
