Preferred Label : Exicorilant;
NCIt synonyms : Glucocorticoid Receptor Antagonist CORT125281; Methanone, ((4aR,8aS)-1-(4-Fluorophenyl)-1,4,5,6,7,8,8a,9-octahydro-6-((2-methyl-2H-1,2,3-triazol-4-yl)sulfonyl)-4ah-pyrazolo(3,4-g)isoquinolin-4a-yl)(4-(trifluoromethyl)-2-pyridinyl)-; WHO 10854;
NCIt definition : An orally available, selective glucocorticoid receptor (GR) antagonist, with potential
antineoplastic activity. Upon oral administration, exicorilant competitively and selectively
binds to GRs, inhibiting the activation of GR-mediated proliferative and anti-apoptotic
gene expression pathways. The GR, a member of the nuclear receptor superfamily of
ligand-dependent transcription factors, is overexpressed in certain tumor types and
may be associated with tumor cell proliferation and treatment resistance. Inhibition
of GR activity may potentially slow tumor cell growth and disease progression in certain
cancers.;
UNII : GTB859B7K8;
InChIKey : HWJYJKAURRIWJM-GKVSMKOHSA-N;
CAS number : 1781244-77-6;
Molecule name : CORT125281; CORT-1252; CORT 125281;
NCI Metathesaurus CUI : CL554423;
Origin ID : C153309;
UMLS CUI : C5235407;
Semantic type(s)
- concept_is_in_subset
- has_target
