Preferred Label : Triamcinolone;
NCIt synonyms : (11beta,16alpha)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;
NCIt related terms : Aristocort;
NCIt definition : A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor,
which leads to translocation of the ligand-receptor complex to the nucleus and induces
expression of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit
phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids
and preventing the synthesis of prostaglandins and leukotrienes, both mediators of
inflammation. In addition, pro-inflammatory cytokine production, including interleukin
(IL)-1and IL-6, and the activation of cytotoxic T-lymphocytes is also inhibited. T-cells
are prevented from making IL-2 and proliferating. This agent also decreases the number
of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis
through increasing Ikappa-B expression and curtailing activation of nuclear factor
(NF)kappa-B.;
Alternative definition : NCI-GLOSS: A substance that is being studied for the prevention of nonmelanoma skin
cancer. It is an anti-inflammatory drug that is applied to the skin to relieve irritation,
rashes, and infections. It belongs to the family of drugs called topical corticosteroids.;
UNII : 1ZK20VI6TY;
InChIKey : GFNANZIMVAIWHM-OBYCQNJPSA-N;
CAS number : 124-94-7;
Drug name : Aristocort;
Chemical formula : C21H27FO6;
NSC code : 13397;
ChEBI ID : CHEBI:9667;
Codes from synonyms : 07584; NSC0013397; CDR0000045206;
Origin ID : C901;
UMLS CUI : C0040864;
See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
