Triamcinolone - CISMeF

Preferred Label : Triamcinolone;

NCIt synonyms : (11beta,16alpha)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;

NCIt related terms : Aristocort;

NCIt definition : A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to translocation of the ligand-receptor complex to the nucleus and induces expression of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, pro-inflammatory cytokine production, including interleukin (IL)-1and IL-6, and the activation of cytotoxic T-lymphocytes is also inhibited. T-cells are prevented from making IL-2 and proliferating. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis through increasing Ikappa-B expression and curtailing activation of nuclear factor (NF)kappa-B.;

Alternative definition : NCI-GLOSS: A substance that is being studied for the prevention of nonmelanoma skin cancer. It is an anti-inflammatory drug that is applied to the skin to relieve irritation, rashes, and infections. It belongs to the family of drugs called topical corticosteroids.;

UNII : 1ZK20VI6TY;

InChIKey : GFNANZIMVAIWHM-OBYCQNJPSA-N;

CAS number : 124-94-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 124-94-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Aristocort;

Chemical formula : C21H27FO6;

NSC code : 13397;

ChEBI ID : CHEBI:9667;

Codes from synonyms : 07584; NSC0013397; CDR0000045206;

Details

Origin ID

C901;

UMLS CUI

C0040864;

Automatic exact mappings (from CISMeF team)
- Triamcinolone [ICHI extension code]
See also inter- (CISMeF)
- Product containing triamcinolone (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing triamcinolone (medicinal product) [SNOMED CT concept]
- Triamcinolone [ICD-11 Extension code]
- Triamcinolone [LOINC component]
- Triamcinolone (substance) [SNOMED CT concept]
- triamcinolone [ATC Code]
- triamcinolone [ATC Code]
- triamcinolone [ATC Code]
- triamcinolone [ATC Code]
- triamcinolone [ATC Code]
- triamcinolone [ATC Code]
- triamcinolone [ATC Code]
- triamcinolone [ATC Code]
- triamcinolone [Substance BNPC]
- triamcinolone [MeSH concept]
- triamcinolone [MeSH Descriptor]
- triamcinolone preparation [SNOMED Notion]
Validated automatic mappings to BTNT
- triamcinolone [ATC Code]
- triamcinolone [ATC Code]
- triamcinolone [ATC Code]
- triamcinolone [ATC Code]
- triamcinolone [ATC Code]
- triamcinolone [ATC Code]
- triamcinolone [ATC Code]
- triamcinolone [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Glucocorticoid Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Eflornithine/Triamcinolone [NCIt concept]

Keyword's position in hierarchy(ies) :

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