Mometasone Furoate

Preferred Label : Mometasone Furoate;

NCIt synonyms : (11beta,16alpha)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione;

NCIt related terms : Elocon; Nasonex;

NCIt definition : The furoate ester form of mometasone, a synthetic topical glucocorticoid receptor (GR) agonist with anti-inflammatory, anti-pruritic and vasoconstrictive properties. Upon administration, mometasone binds to cytoplasmic GRs and subsequently activates GR-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, mometasone appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2.;

Alternative definition : NCI-GLOSS: A drug that is used in a cream to treat certain skin conditions and in a nasal spray to treat sinus problems caused by allergies. It is being studied as a way to treat inflammation of the skin caused by radiation therapy. Elocon is a type of corticosteroid.;

UNII : 04201GDN4R;

InChIKey : WOFMFGQZHJDGCX-ZULDAHANSA-N;

CAS number : 83919-23-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 83919-23-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Nasonex; Elocon; Propel;

Molecule name : Sch-32088;

Chemical formula : C27H30Cl2O6;

ChEBI ID : CHEBI:47564;

Codes from synonyms : CDR0000572209; CDR0000572208; CDR0000538643; 20540;

Origin ID

C29268;

UMLS CUI

C0066700;

CISMeF manual mappings
- Mometasone Furoate [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Mometasone Furoate [MeSH Descriptor]
- Mometasone furoate (substance) [SNOMED CT concept]
- mometasone furoate [MeSH concept]
- mometasone furoate [SNOMED Notion]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_free_acid_or_base_form
- Mometasone [NCIt concept]
has_target
- Glucocorticoid Receptor [NCIt concept]
is_salt_form_of
- Mometasone [NCIt concept]

Keyword's position in hierarchy(ies) :

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