NCIt definition : An ophthalmic suspension containing the acetate form of fluorometholone, with potential
anti-infective and immunosuppressive activities. Upon ocular administration, fluorometholone
binds to glucocorticoid receptors in the cytoplasm and forms a receptor-ligand complex,
which translocates to the nucleus where it binds to glucocorticoid response elements
(GRE) in the promoter region of target genes. This leads to the expression of specific
target genes that control inflammation. Specifically, by inducing the expression of
lipocortins that inhibit the enzymatic activity of phospholipase A2, the release of
arachidonic acid is blocked, which prevents the production of inflammatory mediators,
and inflammatory-induced ocular swelling, redness and itching.;
Semantic type(s)