" /> Methylprednisolone Sodium Succinate - CISMeF





Preferred Label : Methylprednisolone Sodium Succinate;

NCIt related terms : Solu-Medrone; Solu-Medrol;

NCIt definition : The sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects. Methylprednisolone sodium succinate is converted into active prednisolone in the body, which activates glucocorticoid receptor mediated gene expression. This includes inducing synthesis of anti-inflammatory protein IkappaB-alpha and inhibiting synthesis of nuclear factor kappaB (NF-kappaB). As a result, proinflammatory cytokine production such as IL-1, IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.;

UNII : LEC9GKY20K;

InChIKey : FQISKWAFAHGMGT-SGJOWKDISA-M;

CAS number : 2375-03-3;

Drug name : Solu-Medrone; Asmacortone; Prednilem; Cryosolona; Medrate; Solu-Medrol; Solu Moderin; Metypred; A-MethaPred;

Chemical formula : C26H33O8.Na;

NSC code : 48989;

Codes from synonyms : NSC0048989;

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04/05/2025


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