Preferred Label : Fluticasone Propionate;
NCIt synonyms : (6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic
Acid, S-(Fluoromethyl) Ester;
NCIt definition : The propionate salt form of fluticasone, a synthetic trifluorinated glucocorticoid
receptor agonist with antiallergic, antiinflammatory and antipruritic effects. Binding
and activation of the glucocorticoid receptor results in the activation of lipocortin
that in turn inhibits cytosolic phospholipase A2, which triggers cascade of reactions
involved in synthesis of inflammatory mediators, such as prostaglandins and leukotrienes.
Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby
leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting
c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor
(NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which
is essential for prostaglandin production.;
UNII : O2GMZ0LF5W;
InChIKey : WMWTYOKRWGGJOA-CENSZEJFSA-N;
CAS number : 80474-14-2;
Drug name : Flovent; Flonase;
Chemical formula : C25H31F3O5S;
ChEBI ID : CHEBI:31441;
Codes from synonyms : 50239;
Origin ID : C29061;
UMLS CUI : C0117996;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_target
