Preferred Label : Budesonide;
NCIt synonyms : Pregna-1,4-diene-3,20-dione,16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11beta,16alpha)-; (RS)-11beta,16alpha,17,21,-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal
w/ Butyraldehyde;
NCIt definition : A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Upon administration, budesonide binds to intracellular glucocorticoid receptors (GRs)
and induces the expression of glucocorticoid-responsive genes that encode for anti-inflammatory
mediators, such as certain anti-inflammatory cytokines, including interleukin 10 (IL-10),
and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release
of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins
and leukotrienes, both mediators of inflammation. In addition, budesonide prevents
the release of pro-inflammatory cytokines from epithelial cells and macrophages, including
interleukin 6 (IL-6), IL-8, interferon-beta (IFNb), and inhibits nuclear factor kappa-B
(NF-kB) activation thereby decreasing NF-kB-mediated inflammation.;
Alternative definition : NCI-GLOSS: A drug used in the treatment of asthma and rhinitis. It is also being studied
in the treatment of cancer. Budesonide belongs to the family of drugs called steroids.;
UNII : Q3OKS62Q6X;
InChIKey : VOVIALXJUBGFJZ-KWVAZRHASA-N;
CAS number : 51333-22-3;
Drug name : Preferid; Eltair; Budecort; Butacort; Pulmicort; Nasocort; Rhinocort; Pulmicort Turbuhaler;
ChEBI ID : CHEBI:3207;
Codes from synonyms : CDR0000046151; 09228;
Origin ID : C1027;
UMLS CUI : C0054201;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_target
