Budesonide - CISMeF

Preferred Label : Budesonide;

NCIt synonyms : Pregna-1,4-diene-3,20-dione,16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11beta,16alpha)-; (RS)-11beta,16alpha,17,21,-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal w/ Butyraldehyde;

NCIt definition : A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon administration, budesonide binds to intracellular glucocorticoid receptors (GRs) and induces the expression of glucocorticoid-responsive genes that encode for anti-inflammatory mediators, such as certain anti-inflammatory cytokines, including interleukin 10 (IL-10), and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, budesonide prevents the release of pro-inflammatory cytokines from epithelial cells and macrophages, including interleukin 6 (IL-6), IL-8, interferon-beta (IFNb), and inhibits nuclear factor kappa-B (NF-kB) activation thereby decreasing NF-kB-mediated inflammation.;

Alternative definition : NCI-GLOSS: A drug used in the treatment of asthma and rhinitis. It is also being studied in the treatment of cancer. Budesonide belongs to the family of drugs called steroids.;

UNII : Q3OKS62Q6X;

InChIKey : VOVIALXJUBGFJZ-KWVAZRHASA-N;

CAS number : 51333-22-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 51333-22-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Preferid; Eltair; Budecort; Butacort; Pulmicort; Nasocort; Rhinocort; Pulmicort Turbuhaler;

ChEBI ID : CHEBI:3207;

Codes from synonyms : CDR0000046151; 09228;

Details

Origin ID

C1027;

UMLS CUI

C0054201;

Automatic exact mappings (from CISMeF team)
- Budesonide [ICHI extension code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Budesonide [ICD-11 Extension code]
- Budesonide [LOINC component]
- Budesonide (substance) [SNOMED CT concept]
- Product containing budesonide (medicinal product) [SNOMED CT concept]
- budesonide [ATC Code]
- budesonide [ATC Code]
- budesonide [ATC Code]
- budesonide [ATC Code]
- budesonide [Substance BNPC]
- budesonide [MeSH concept]
- budesonide [MeSH Descriptor]
Validated automatic mappings to BTNT
- budesonide [ATC Code]
- budesonide [ATC Code]
- budesonide [ATC Code]
- budesonide [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_target
- Glucocorticoid Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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