Clobetasol - CISMeF

Preferred Label : Clobetasol;

NCIt definition : A topical synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties. Upon topical administration, clobetasol binds to cytoplasmic glucocorticoid receptors (GRs) and activates GR-mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, clobetasol induces phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2. This inhibits skin inflammation, and reduces swelling, redness, itching and rashes.;

UNII : ADN79D536H;

InChIKey : FCSHDIVRCWTZOX-DVTGEIKXSA-N;

CAS number : 25122-41-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 25122-41-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C22H28ClFO4;

ChEBI ID : CHEBI:205919;

Details

Origin ID

C65339;

UMLS CUI

C0008992;

Automatic exact mappings (from CISMeF team)
- Clobetasol [ICHI extension code]
See also inter- (CISMeF)
- Product containing clobetasol (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Clobetasol [ICD-11 Extension code]
- Clobetasol (substance) [SNOMED CT concept]
- Product containing clobetasol (medicinal product) [SNOMED CT concept]
- clobetasol [ATC Code]
- clobetasol [Substance BNPC]
- clobetasol [MeSH Descriptor]
- clobetasol [MeSH concept]
- clobetasol [SNOMED Notion]
Validated automatic mappings to BTNT
- clobetasol [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_target
- Glucocorticoid Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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