Clobetasol Propionate

Preferred Label : Clobetasol Propionate;

NCIt synonyms : Olux-E;

NCIt definition : The propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties. Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2.;

UNII : 779619577M;

InChIKey : CBGUOGMQLZIXBE-XGQKBEPLSA-N;

CAS number : 25122-46-7;

Chemical formula : C25H32ClFO5;

ChEBI ID : CHEBI:31414;

Codes from synonyms : 30204;

Details

Origin ID

C28934;

UMLS CUI

C0055895;

Automatic exact mappings (from CISMeF team)
- clobetasol [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- clobetasol [MeSH Descriptor]
- clobetasol [Substance BNPC]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Clobetasol [NCIt concept]
has_target
- Glucocorticoid Receptor [NCIt concept]
is_component_of_chemotherapy_regimen
- Topical Clobetasol Regimen [NCIt concept]
- Topical Clobetasol/Mechlorethamine Regimen [NCIt concept]
is_salt_form_of
- Clobetasol [NCIt concept]

Keyword's position in hierarchy(ies) :

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