NCIt definition : A topical cream containing the synthetic glucocorticoid fluocinonide, with anti-inflammatory
and antipruritic activities. Upon administration of the fluocinonide cream to the
affected area(s), fluocinonide binds to the cytosolic glucocorticoid receptor, followed
by translocation of the ligand-receptor complex to the nucleus and transcription activation
of genes containing glucocorticoid-responsive elements (GREs), which increases the
expression of specific target genes, such as lipocortin-1 (annexin A1). The induction
of lipocortin-1 expression by fluocinonide leads to an increased interaction and inhibition
of cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation
to the perinuclear membrane and subsequent release and conversion of arachidonic acid
to inflammatory prostaglandins and leukotrienes. This may relieve symptoms associated
with skin inflammation.;
Semantic type(s)