Estrogen Receptor Regulation by CARM1 Pathway

Preferred Label : Estrogen Receptor Regulation by CARM1 Pathway;

NCIt related terms : CARM1 and Regulation of the Estrogen Receptor;

Alternative definition : BIOCARTA: Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine methyltransferase 1) has been observed to play a key role in transcriptional regulation. CARM1 associates with the p160 class of transcriptional coactivators involved in gene activation by steroid hormone family receptors. CARM1 also interacts with CBP/p300 transcriptional coactivators involved in gene activation by a large variety of transcription factors, including steroid hormone receptors and CEBP. One target of CARM1 is the core histones H3 and H4, which are also targets of the histone acetylase activity of CBP/p300 coactivators. Recruitment of CARM1 to the promoter region by binding to coactivators increases histone methylation and makes promoter regions more accessible for transcription. Another target of CARM1 methylation is a coactivator it interacts with, CBP. Methylation of CBP by CARM1 blocks CBP from acting as a coactivator for CREB and redirects the limited CBP pool in the cell to be available for steroid hormone receptors. Other forms of post-translational protein modification such as phosphorylation are reversible in nature, but as of yet a protein demethylase is not known. The methylation activity of CARM1 modulates the activity of specific transcriptional regulators. CARM1 acts as a coactivator for the myogenic transcription factor Mef2c, and is necessary for normal muscle cell differentiation. The estrogen receptor is another transcription factor that uses CARM1 as one of several coactivators, acting synergistically with CBP through the Grip1 member of the p160 family of coactivators. The interaction of estrogen receptor with various ligand-dependent coactivators may produce the tissue selective response of some estrogen receptor ligands like tamoxifen. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_carm-erPathway;

Details

Origin ID

C39013;

UMLS CUI

C1516973;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Breast Cancer Type 1 Susceptibility Protein [NCIt concept]
- CREB-Binding Protein [NCIt concept]
- DNA-Directed RNA Polymerase II Subunit RPB1 [NCIt concept]
- Estrogen Receptor [NCIt concept]
- G1/S-Specific Cyclin-D1 [NCIt concept]
- General Transcription Factor IIE Subunit 1 [NCIt concept]
- General Transcription Factor IIF Subunit 1 [NCIt concept]
- Glucocorticoid Receptor [NCIt concept]
- Histone Acetyltransferase p300 [NCIt concept]
- Histone Deacetylase 1 [NCIt concept]
- Histone Deacetylase 2 [NCIt concept]
- Histone Deacetylase 3 [NCIt concept]
- Histone Deacetylase 4 [NCIt concept]
- Histone Deacetylase 5 [NCIt concept]
- Histone Deacetylase 6 [NCIt concept]
- Histone-Arginine Methyltransferase CARM1 [NCIt concept]
- Mediator of RNA Polymerase II Transcription Subunit 1 [NCIt concept]
- Nuclear Receptor Corepressor 2 [NCIt concept]
- Nuclear Receptor-Interacting Protein 1 [NCIt concept]
- TATA-Box-Binding Protein [NCIt concept]
- TFIIH Basal Transcription Factor Complex Helicase XPB Subunit [NCIt concept]
- Transcription Initiation Factor IIA [NCIt concept]
- Transcription Initiation Factor IIA Alpha Chain [NCIt concept]
- Transcription Initiation Factor IIA Beta Chain [NCIt concept]
- Transcription Initiation Factor IIA Subunit 2 [NCIt concept]
pathway_has_gene_element
- BRCA1 wt Allele [NCIt concept]
- CARM1 wt Allele [NCIt concept]
- CCND1 wt Allele [NCIt concept]
- CREBBP wt Allele [NCIt concept]
- EP300 wt Allele [NCIt concept]
- ERCC3 wt Allele [NCIt concept]
- ESR1 wt Allele [NCIt concept]
- GTF2A1 wt Allele [NCIt concept]
- GTF2E1 wt Allele [NCIt concept]
- GTF2F1 wt Allele [NCIt concept]
- H3C14 wt Allele [NCIt concept]
- H3C15 wt Allele [NCIt concept]
- HDAC1 wt Allele [NCIt concept]
- HDAC2 wt Allele [NCIt concept]
- HDAC3 wt Allele [NCIt concept]
- HDAC4 wt Allele [NCIt concept]
- HDAC5 wt Allele [NCIt concept]
- MED1 wt Allele [NCIt concept]
- NCOR2 wt Allele [NCIt concept]
- NR3C1 wt Allele [NCIt concept]
- NRIP1 wt Allele [NCIt concept]
- POLR2A wt Allele [NCIt concept]
- TBP wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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