Histone Deacetylase 2

Preferred Label : Histone Deacetylase 2;

NCIt synonyms : HDAC2; Transcriptional Regulator Homolog RPD3; EC 3.5.1.98; HD2; Histone Deacetylase-2; YY1-Associated Factor 1;

NCIt definition : Histone deacetylase 2 (488 aa, 55 kDa) is encoded by the human HDAC2 gene. This protein plays a role in histone deacetylation, chromatin remodeling and embryonic structure development.;

NCIt note : One of three identified histone deacetylases with similarity to the yeast global transcriptional regulator Rpd3p, HDAC2 is found in transcription factor co-repressor complexes that include HDAC1. BRCA1 interacts with HDAC1 and HDAC2. Acetylation of histone destabilizes nucleosomes allowing transcription factors access to recognition elements in DNA. Deacetylation reseals the chromosomal package, repressing transcription. DNMT1 can establish a repressive transcription complex with HDAC2, and DMAP1. HDAC2 joins DNMT1 and DMAP1 during late S-phase, suggesting how histones may become deacetylated in heterochromatin following replication. (from OMIM 605164 and NCI);

Details

Origin ID

C18294;

UMLS CUI

C2713652;

OMIM relation
- Histone deacetylase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- HDAC2 protein, human [MeSH concept]
- HDAC2 protein, human [MeSH Supplementary Concept]
- histone deacetylase 2 [MeSH concept]
- histone deacetylase 2 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HDAC2 Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
gene_product_has_biochemical_function
- Chromatin Remodeling Factor [NCIt concept]
gene_product_has_gene_product_variant
- HDAC2 NP_001518.3:p.E455fs*7 [NCIt concept]
- HDAC2 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cell Cycle Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Estrogen Receptor Regulation by CARM1 Pathway [NCIt concept]
- Gene Silencing Pathway [NCIt concept]
- Huntington's Disease Pathway [NCIt concept]
- Macrophage Differentiation Pathway [NCIt concept]
- Notch Signaling Pathway [NCIt concept]
- T-Cell Apoptosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Deacetylation [NCIt concept]
- Histone Deacetylation [NCIt concept]
- Hydrolysis [NCIt concept]
- Transcriptional Regulation [NCIt concept]
is_target
- Tucidinostat [NCIt concept]

Keyword's position in hierarchy(ies) :

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