NCIt definition : An orally bioavailable benzamide-type inhibitor of histone deacetylase (HDAC) isoenzymes
1, 2, 3 and 10, with potential antineoplastic activity. Upon administration, tucidinostat
binds to and inhibits HDACs, leading to an increase of acetylation levels of histone
proteins. This agent also inhibits the expression of kinases in the PI3K/Akt and MAPK/Ras
signaling pathways and may result in cell cycle arrest and the induction of tumor
cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells.
HDACs, a class of enzymes that deacetylate chromatin histone proteins, are upregulated
in many tumor types and play key roles in gene expression. Compared to some other
benzamide-type HDAC inhibitors, chidamide is more stable, more resistant to degradation
and has a longer half-life.;
UNII : 87CIC980Y0;
InChIKey : SZMJVTADHFNAIS-BJMVGYQFSA-N;
CAS number : 1616493-44-7;
Drug name : Hiyasta;
Molecule name : HBI-8000; CS-055; HBI 8000; CS 055;