" /> Histone Deacetylase 3 - CISMeF





Preferred Label : Histone Deacetylase 3;

NCIt synonyms : HDAC3; SMAP45; RPD3-2; EC 3.5.1.98; HD3; Histone Deacetylase-3;

NCIt definition : Histone deacetylase 3 (428 aa, 49 kDa) is encoded by the human HDAC3 gene. This protein is involved in the negative regulation of apoptosis, histone deacetylation and signal regulation.;

NCIt note : HDAC3 can be found in complexes that include HDAC4 and HDAC5, deacetylases with similarity to yeast Hda1 deacetylase. HDAC3 may regulate transcription through binding the zinc-finger transcription factor YY1, increasing its repression activity. RELA is a nonhistone substrate of HDAC3. IKBA-dependent nuclear export of deacetylated RELA replenishes the cytoplasmic pool of NFKB/IKBA complexes for NFKB responses. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. (OMIM);

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28/05/2025


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