NCIt definition : Histone deacetylase 3 (428 aa, 49 kDa) is encoded by the human HDAC3 gene. This protein
is involved in the negative regulation of apoptosis, histone deacetylation and signal
regulation.;
NCIt note : HDAC3 can be found in complexes that include HDAC4 and HDAC5, deacetylases with similarity
to yeast Hda1 deacetylase. HDAC3 may regulate transcription through binding the zinc-finger
transcription factor YY1, increasing its repression activity. RELA is a nonhistone
substrate of HDAC3. IKBA-dependent nuclear export of deacetylated RELA replenishes
the cytoplasmic pool of NFKB/IKBA complexes for NFKB responses. This protein can also
down-regulate p53 function and thus modulate cell growth and apoptosis. (OMIM);