RELA Pathway - CISMeF

Preferred Label : RELA Pathway;

NCIt related terms : Acetylation and Deacetylation of RelA in The Nucleus;

Alternative definition : BIOCARTA: The rel/NF-kB family of transcription factors regulates the activity of genes involved in the immune response, hematopoiesis, and inflammation. NF-kB is a complex of two proteins, p65 (rel) and p50. NF-kB is held inactive in the cytoplasm by I-kB, until signals initiated by TNF or several other factors lead to the phosphorylation and degradation of I-kB and the subsequent release of NF-kB to bind DNA and activate genes. The activation of transcription by NF-kB requires transcriptional coactivators such as p300 and CBP to interact with the rest of the transcriptional apparatus. These coactivators posses enzyme activity, acting to catalyze the posttranslational acetylation of proteins on lysine groups. Acetylation of histones has been known for some time to occur in transcriptionally active chromatin regions. Histone deacetylase (HDAC) enzymes reverse the acetylation of histones. As with other signals, there an off-switch as well as an on-switch for NF-kB activation. The signal to terminate gene activation by NF-kB involves regulation of NF-kB acetylation. P300 and CBP recruited by NF-kB to the transcriptional complex acetylate RelA. Acetylated NF-kB proteins do not interact with I-kB and so continue stimulating transcription. To turn off NF-kB dependent transcription, the histone deacetylase HDAC3 binds to and deacetylates RelA, which then interacts strongly with I-kB once again and is inactivated. The reformed complex of NF-kB and I-kB is exported from the nucleus to the cytoplasm where it replenishes the pool of inactive NF-kB awaiting the next activation signal. The activity of other proteins may also be regulated by acetylation in a similar manner. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_RELAPathway;

Details

Origin ID

C39221;

UMLS CUI

C1514645;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- CREB-Binding Protein [NCIt concept]
- FAS-Associated Death Domain Protein [NCIt concept]
- Histone Acetyltransferase p300 [NCIt concept]
- Histone Deacetylase 3 [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Receptor-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- TNF Receptor-Associated Factor 6 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Tumor Necrosis Factor Receptor 1-Associated DEATH Domain Protein [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 1A [NCIt concept]
pathway_has_gene_element
- CHUK wt Allele [NCIt concept]
- CREBBP wt Allele [NCIt concept]
- EP300 wt Allele [NCIt concept]
- FADD wt Allele [NCIt concept]
- HDAC3 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- RIPK1 wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]
- TNFRSF1A wt Allele [NCIt concept]
- TRADD wt Allele [NCIt concept]
- TRAF6 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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