FAS-Associated Death Domain Protein

Preferred Label : FAS-Associated Death Domain Protein;

NCIt synonyms : FAS-Associated Protein with A Death Domain; MORT1; FAS-Associating Death Domain-Containing Protein; FADD; Fas-Associated Via Death Domain Protein; Fas-Associated Via Death Domain; FAS-Associating Protein With Death Domain; Mediator of Receptor-Induced Toxicity; Growth-Inhibiting Gene 3 Protein; Protein FADD; Mediator of Receptor Induced Toxicity;

NCIt definition : FAS-associated death domain protein (208 aa, 23 kDa) is encoded by the human FADD gene. This protein is involved in the positive regulation of caspase-dependent apoptosis.;

NCIt note : FAS-associated death domain protein acts as an adaptor protein, interacting with FAS or TNFR-2. The death domain of these receptors binds to the corresponding domain of FADD, which in turn recruits the zymogen form of the death protease FLICE, activating a protease cascade which results in apoptosis.;

Details

Origin ID

C26106;

UMLS CUI

C1527783;

Currated CISMeF NLP mapping
- Fas-Associated death domain protein [MeSH Descriptor]
- Fas-Associated death domain protein [MeSH concept]
OMIM relation
- Fas-associated via death domain [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- FADD protein, human [MeSH Supplementary Concept]
- FADD protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- FADD Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Death Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Ceramide Signaling Pathway BioCarta [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
- Fas Signaling Pathway BioCarta [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- NFKB Signaling Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- RELA Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- SODD/TNFR1 Signaling Pathway [NCIt concept]
- TNFR1 Signaling Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
- T-Cell Differentiation [NCIt concept]

Keyword's position in hierarchy(ies) :

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