Receptor-Interacting Serine/Threonine-Protein Kinase 1

Preferred Label : Receptor-Interacting Serine/Threonine-Protein Kinase 1;

NCIt synonyms : Receptor-Interacting Protein; RIP; RIP Protein Kinase; RIPK1; Receptor-Interacting Serine/Threonine Kinase 1; RIP-1; Cell Death Protein RIP; RIP1; EC 2.7.11.1; Receptor-Interacting Protein 1; Serine/Threonine-Protein Kinase RIP; Receptor-Interacting Serine-Threonine Kinase-1; Receptor Interacting Protein;

NCIt definition : Receptor-interacting serine/threonine-protein kinase 1 (671 aa, 76 kDa) is encoded by the human RIPK1 gene. This protein plays a role in signaling that mediates inflammation, serine/threonine phosphorylation and cell death.;

NCIt note : RIP1 interacts with the cytoplasmic domain of FAS, and with TNFR1 through the adaptor proteins TRADD and TRAFs 1, 2, and 3.;

Details

Origin ID

C17923;

UMLS CUI

C0297981;

OMIM relation
- Receptor-interacting serine/threonine kinase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- RIPK1 protein, human [MeSH Supplementary Concept]
- RIPK1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- RIPK1 Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Death Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Apoptosis Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- Ceramide Signaling Pathway BioCarta [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- Cytosolic DNA-Sensing Pathway [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
- FAS Signaling Pathway PID [NCIt concept]
- HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- NFKB Signaling Pathway [NCIt concept]
- RELA Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- Regulation of p38-alpha and p38-beta Pathway [NCIt concept]
- SODD/TNFR1 Signaling Pathway [NCIt concept]
- TNF Receptor Family Signaling Pathway [NCIt concept]
- TNF Stress Related Signaling Pathway [NCIt concept]
- TNFR1 Signaling Pathway [NCIt concept]
- TNFR2 Signaling Pathway [NCIt concept]
- TRAIL Signaling Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- p38 MAPK Signaling Pathway BioCarta [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- RIP1 Inhibitor GDC-8264 [NCIt concept]
- RIPK1 Inhibitor GSK3145095 [NCIt concept]

Keyword's position in hierarchy(ies) :

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