Flizasertib - CISMeF

Preferred Label : Flizasertib;

NCIt synonyms : RIP1 Inhibitor GDC-8264; RIP1 Kinase Inhibitor GDC-8264; RIPK1 Inhibitor GDC-8264;

NCIt definition : An orally available inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK1; receptor-interacting protein 1; RIP1) with potential immunomodulatory and anti-inflammatory activities. Upon oral administration, flizasertib inhibits RIP1-mediated signaling, which may preserve intestinal stem cells (ISCs) and prevent RIP1-mediated gastrointestinal (GI) damage in acute graft-versus-host disease (GvHD). RIP1 plays a key role in inflammation and cell death in response to tissue damage and pathogen recognition.;

UNII : 9HU54LL76C;

CAS number : 2268739-68-8;

Molecule name : GDC 8264; RO 7288817; RO-7288817; GDC-8264; RG 6287; RG-6287;

NCI Metathesaurus CUI : CL1906474;

Details

Origin ID

C199052;

UMLS CUI

C5855330;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Receptor-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients