TNFR2 Signaling Pathway

Preferred Label : TNFR2 Signaling Pathway;

Alternative definition : BIOCARTA: TNFR2 is the receptor for the 171 amino acid 19 kD TNF-beta (a.k.a. lymphotoxin). TNF-beta is produced by activated lymphocytes and can be cytotoxic to many tumor and other cells. In neutrophils, endothelial cells and osteoclasts TNF-beta can lead to activation while in many other cell types it can lead to increased expression of MHC and adhesion molecules. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_tnfr2Pathway;

Details

Origin ID

C39255;

UMLS CUI

C1515166;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- Dual Specificity Protein Phosphatase 1 [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Lymphotoxin-Alpha [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 14 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Receptor-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- TNF Receptor-Associated Factor 1 [NCIt concept]
- TNF Receptor-Associated Factor 2 [NCIt concept]
- TNF Receptor-Associated Factor 3 [NCIt concept]
- TRAF Family Member-Associated NF-Kappa-B Activator [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Tumor Necrosis Factor Alpha-Induced Protein 3 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 1B [NCIt concept]
pathway_has_gene_element
- CHUK wt Allele [NCIt concept]
- DUSP1 wt Allele [NCIt concept]
- LTA wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MAP3K14 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- RIPK1 wt Allele [NCIt concept]
- TANK wt Allele [NCIt concept]
- TNFAIP3 wt Allele [NCIt concept]
- TNFRSF1B wt Allele [NCIt concept]
- TRAF1 wt Allele [NCIt concept]
- TRAF2 wt Allele [NCIt concept]
- TRAF3 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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