Preferred Label : LTA wt Allele;
NCIt synonyms : Tumor Necrosis Factor, Beta Gene; TNFSF1; Lymphotoxin-Alpha Gene; Lymphotoxin Alpha wt Allele; DAMA-25N12.13-004; LT; TNFB; TNF Superfamily, Member 1 Gene; TNF, Lymphocyte-Derived Gene; Lymphotoxin Alpha (TNF Superfamily, Member 1) Gene;
NCIt definition : Human LTA wild-type allele is located in the vicinity of 6p21.3 and is approximately
2 kb in length. This allele, which encodes lymphotoxin-alpha protein, is involved
in the mediation of a large variety of inflammatory, immunostimulatory, and antiviral
responses. In addition, the allele plays a role in secondary lymphoid organs during
development and in apoptosis.;
NCIt note : Human LTA Gene (TNF family) at 6p21.3 encodes TNF Beta, a glycoprotein cytokine of
activated lymphocytes having cytotoxic and necrotic effects. Between C4 and HLA-B
in the MHC region, TNFC resides just centromeric to TNFA, which is just centromeric
to TNFB. These three similar genes lie about 200 kb from HLA-B. TNFC transcribes telomerically,
TNFB and TNFA centromerically. MHC polymorphic microsatellites within a 12 kb region
include TNFB. A putative immune response modulator similar to TNF Alpha, homotrimeric
TNF Beta shares TNFR-1 and -2 receptors with TNF Alpha.;
GenBank Accession Number : NM_000595;
Origin ID : C51509;
UMLS CUI : C1706393;
OMIM relation
- Semantic type(s)
- gene_associated_with_disease
- gene_found_in_organism
- gene_has_physical_location
- gene_in_chromosomal_location
- gene_is_element_in_pathway
- gene_plays_role_in_process
