Lymphotoxin-Alpha

Preferred Label : Lymphotoxin-Alpha;

NCIt synonyms : TNF Beta; LTA; Lymphotoxin Alpha; TNF-b; TNFSF1; Lymphotoxin A; LT; TNF Superfamily Member 1; Lymphotoxin-A; Tumor Necrosis Factor Ligand Superfamily Member 1; TNF-Beta; LT-Alpha; Tumor Necrosis Factor Beta; Tumor Necrosis Factor-Beta;

NCIt definition : Lymphotoxin-alpha (205 aa, 22 kDa) is encoded by the human LTA gene. This protein plays a role in cell-cell signaling and the positive regulation of apoptosis.;

NCIt note : The lymphotoxin complex is comprised of a homotrimer of lymphotoxin-alpha (LTA) or a heterotrimer of either two lymphotoxin-beta (LTB) and one LTA subunits or one LTB and two LTA subunits; the latter heterotrimeric complex is less prevalent. (UniProt);

Details

Origin ID

C20536;

UMLS CUI

C3887647;

Currated CISMeF NLP mapping
- lymphotoxin [SNOMED Notion]
- lymphotoxin-alpha [MeSH Descriptor]
- lymphotoxin-alpha [MeSH concept]
- tumor necrosis factor beta [SNOMED Notion]
False automatic mappings
- Tumor necrosis factor beta (substance) [SNOMED CT concept]
OMIM relation
- Lymphotoxin-alpha [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
endogenous_product_related_to
- Recombinant Tumor Necrosis Factor-Beta [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- LTA Gene [NCIt concept]
- Tumor Necrosis Factor Family Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Regulator [NCIt concept]
- Lymphokine [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Apoptosis Pathway [NCIt concept]
- BCR Signaling Pathway [NCIt concept]
- Cytokine Network Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- IL2/STAT5 Signaling Pathway [NCIt concept]
- IL4-Mediated Signaling Pathway [NCIt concept]
- Inflammatory Response Pathway [NCIt concept]
- TNFR2 Signaling Pathway [NCIt concept]
- Type I Diabetes Mellitus Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Death Process [NCIt concept]
- Cell-Mediated Cytotoxicity [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Necrotic Process [NCIt concept]
- Tumor Necrosis Factor Receptor Binding [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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