Preferred Label : Mitogen-Activated Protein Kinase Kinase Kinase 14;
NCIt synonyms : NFKB-Inducing Kinase; Serine-Threonine Protein Kinase-NIK; MAP3K14 Protein; MAP3K14; NIK; HSNIK; NF-Kappa-Beta-Inducing Kinase; Serine/Threonine Protein Kinase NIK;
NCIt definition : Mitogen-activated protein kinase kinase kinase 14 (947 aa, 104 kDa) is encoded by
the human MAP3K14 gene. This protein is involved in both serine/threonine phosphorylation
and NF-kappaB signaling pathways.;
NCIt note : Ser/Thr Protein Kinase NIK is involved in NFKB activation. NIK selectively activates
NFKB cascades of TNF/NGF receptors and IL1R type-I. TNFA acts through TRAF2; IL1 acts
through IRAK1 and TRAF6. LTBR and CD95 also act through NIK. NIK appears to bind TRAFs
2, 5, and 6, IKKA, and NFKB2/p100. Binding to TRAF2 involves the TRAF2 N- and C-terminal
regions. NIK induces NFKB2/p100 processing, degradation of phosphoserine-induced ubiquitinated
destruction of IKBA, and release of cytoplasmic NFKB for nuclear translocation and
kappa-B DNA-mediated gene expression. (from LocusLink, Swiss-Prot, OMIM, and NCI);
Origin ID : C26487;
UMLS CUI : C1335946;
OMIM relation
- Semantic type(s)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_organism_source
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
