B-Cell Immune Response Pathway

Preferred Label : B-Cell Immune Response Pathway;

NCIt related terms : TACI and BCMA stimulation of B cell immune responses;

Alternative definition : BIOCARTA: APRIL and BAFF (also called TALL-I and BLyS) are TNF family members that act as ligands for the BCMA and TACI receptors. Both APRIL and BAFF bind to both the BCMA and TACI receptors to activate the humoral immune response, stimulating B cell immunoglobulin production and proliferation. BAFF is found as a membrane bound form in T cells and a soluble form that is released from the cell to stimulate B cell proliferation and differentiation. As members of the TNF receptor gene family, BCMA and TACI interact with TRAF family members to transduce signals downstream to NF-kappaB activation and MAP kinase pathways. Abnormally active BAFF or APRIL signaling may play a role in autoimmune disorders such as lupus. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_tall1Pathway;

Details

Origin ID

C39243;

UMLS CUI

C1511003;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B [NCIt concept]
- Denticleless Protein Homolog [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 7 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 [NCIt concept]
- TNF Receptor-Associated Factor 2 [NCIt concept]
- TNF Receptor-Associated Factor 3 [NCIt concept]
- TNF Receptor-Associated Factor 6 [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 13 [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 13B [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 13C [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 17 [NCIt concept]
pathway_has_gene_element
- ANP32B wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- DTL wt Allele [NCIt concept]
- MAP3K14 wt Allele [NCIt concept]
- MAP3K7 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- TNFRSF13C wt Allele [NCIt concept]
- TNFRSF17 wt Allele [NCIt concept]
- TNFSF13 wt Allele [NCIt concept]
- TNFSF13B wt Allele [NCIt concept]
- TRAF2 wt Allele [NCIt concept]
- TRAF3 wt Allele [NCIt concept]
- TRAF6 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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