Tumor Necrosis Factor Ligand Superfamily Member 13B

Preferred Label : Tumor Necrosis Factor Ligand Superfamily Member 13B;

NCIt synonyms : B Lymphocyte Stimulator; TALL-1; CD257; CD257 Antigen; Dendritic Cell-Derived TNF-Like Molecule; BLyS; BAFF; TNF- and APOL-Related Leukocyte Expressed Ligand 1; B-Cell-Activating Factor; Antigen CD257; TNF Homolog That Activates Apoptosis, NKFB, and JNK; B-Lymphocyte Stimulator; TNFSF13B;

CISMeF acronym : TNFSF13B;

NCIt definition : Tumor necrosis factor ligand superfamily member 13B (285 aa, 31 kDa) is encoded by the human TNFSF13B gene. This protein is involved in signal transduction and the modulation of B- and T-cell proliferation.;

NCIt note : Tumor necrosis factor ligand superfamily member 13B may be involved in signaling that leads to MYC upregulation in chronic lymphocytic leukemia. (PNAS 2010; 107: 18956-18960.); Tumor necrosis factor ligand superfamily member 13B is a ligand for the receptors TNFRSF13B, TNFRSF17, and TNFRSF13C. It is a transmembrane protein that can be post-translationally cleaved to release a soluble product.;

Details

Origin ID

C94789;

UMLS CUI

C1682317;

Currated CISMeF NLP mapping
- B-Cell activating factor [MeSH concept]
- b-cell activating factor [MeSH Descriptor]
OMIM relation
- Tumor necrosis factor ligand superfamily, member 13b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TNFSF13B protein, human [MeSH concept]
- TNFSF13B protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- TNFSF13B Gene [NCIt concept]
- Tumor Necrosis Factor Family Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Regulator [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- B-Cell Immune Response Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Intestinal IgA Production Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Death Process [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tumor Necrosis Factor Receptor Binding [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]
is_target
- Belimumab [NCIt concept]
- Tabalumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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