NCIt synonyms : Immunoglobulin G1, anti-(Human Cytokine BAFF) (Human Monoclonal LymphoStat-B Heavy
Chain), Disulfide with Human Monoclonal LymphoStat-B lambda-chain, Dimer;
NCIt definition : A fully human IgG1 monoclonal antibody directed against B-Lymphocyte stimulator protein
(BlyS or TNFSF13B) with potential immunomodulating activity. Belimumab specifically
recognizes and inhibits the biological activity of BlyS, thereby preventing the binding
of BlyS to B-lymphocytes. This inhibits the maturation of B-lymphocytes and may induce
apoptosis in B-lymphocytes. In addition, it may decrease B-lymphocyte proliferation
and/or survival. BlyS, a member of TNF family supporting B-lymphocyte maturation and
survival, has been implicated in the pathogenesis of autoimmune diseases and B-lymphocyte
malignancies.;