Belimumab - CISMeF

Preferred Label : Belimumab;

NCIt synonyms : Immunoglobulin G1, anti-(Human Cytokine BAFF) (Human Monoclonal LymphoStat-B Heavy Chain), Disulfide with Human Monoclonal LymphoStat-B lambda-chain, Dimer;

NCIt definition : A fully human IgG1 monoclonal antibody directed against B-Lymphocyte stimulator protein (BlyS or TNFSF13B) with potential immunomodulating activity. Belimumab specifically recognizes and inhibits the biological activity of BlyS, thereby preventing the binding of BlyS to B-lymphocytes. This inhibits the maturation of B-lymphocytes and may induce apoptosis in B-lymphocytes. In addition, it may decrease B-lymphocyte proliferation and/or survival. BlyS, a member of TNF family supporting B-lymphocyte maturation and survival, has been implicated in the pathogenesis of autoimmune diseases and B-lymphocyte malignancies.;

UNII : 73B0K5S26A;

CAS number : 356547-88-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 356547-88-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : LymphoStat-B; Benlysta;

Details

Origin ID

C91385;

UMLS CUI

C1723401;

Automatic exact mappings (from CISMeF team)
- Belimumab [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Belimumab (substance) [SNOMED CT concept]
- belimumab [MeSH concept]
- belimumab [MeSH Supplementary Concept]
- belimumab [International Nonproprietary Name]
See also inter- (CISMeF)
- Product containing belimumab (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Belimumab (substance) [SNOMED CT concept]
- Product containing belimumab (medicinal product) [SNOMED CT concept]
- belimumab [ATC Code]
- belimumab [International Nonproprietary Name]
- belimumab [MeSH concept]
- belimumab [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- belimumab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor Necrosis Factor Ligand Superfamily Member 13B [NCIt concept]

Keyword's position in hierarchy(ies) :

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