Tabalumab - CISMeF

Preferred Label : Tabalumab;

NCIt synonyms : Anti-BAFF Monoclonal Antibody LY2127399;

NCIt definition : A human IgG4 monoclonal antibody against B-cell activating factor (BAFF), with potential immunomodulating and antineoplastic activities. Tabalumab binds to and inhibits the activity of both soluble and cell surface-bound BAFF. This may reduce the activity, proliferation and survival of B-cells. A dysregulated expression of BAFF, a member of the tumor necrosis factor (TNF) family of proteins, is often seen in certain autoimmune diseases and certain cancers, and may promote B lymphocyte activation, proliferation and survival.;

UNII : PQP8VH3MJW;

CAS number : 1143503-67-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1143503-67-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : LY2127399;

Details

Origin ID

C91727;

UMLS CUI

C2984518;

Currated CISMeF NLP mapping
- tabalumab [MeSH Supplementary Concept]
- tabalumab [MeSH concept]
See also inter- (CISMeF)
- Ly-2127399 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- tabalumab [MeSH concept]
- tabalumab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor Necrosis Factor Ligand Superfamily Member 13B [NCIt concept]

Keyword's position in hierarchy(ies) :

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