Intestinal IgA Production Pathway

Preferred Label : Intestinal IgA Production Pathway;

NCIt synonyms : Pathway for IgA Production;

NCIt related terms : Intestinal immune network for IgA production;

Alternative definition : KEGG: The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-committed plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-beta, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.;

KEGG ID : hsa04672;

Details

Origin ID

C91518;

UMLS CUI

C2984326;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- C-C Chemokine Receptor Type 10 [NCIt concept]
- C-C Chemokine Receptor Type 9 [NCIt concept]
- C-C Motif Chemokine 25 [NCIt concept]
- C-C Motif Chemokine 28 [NCIt concept]
- C-X-C Chemokine Receptor Type 4 [NCIt concept]
- CD40 Ligand [NCIt concept]
- HLA Class II Histocompatibility Antigen, DM Alpha Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DM Beta Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DO Beta Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DQ Alpha 1 Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DQ Beta 1 Chain [NCIt concept]
- HLA Class II Histocompatibility Antigen, DR Alpha Chain [NCIt concept]
- ICOS Ligand [NCIt concept]
- Inducible T-Cell Costimulator [NCIt concept]
- Integrin Alpha-4 [NCIt concept]
- Integrin Beta-7 [NCIt concept]
- Interleukin-10 [NCIt concept]
- Interleukin-15 [NCIt concept]
- Interleukin-15 Receptor Subunit Alpha [NCIt concept]
- Interleukin-2 [NCIt concept]
- Interleukin-4 [NCIt concept]
- Interleukin-5 [NCIt concept]
- Interleukin-6 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 14 [NCIt concept]
- Mucosal Addressin Cell Adhesion Molecule 1 [NCIt concept]
- Polymeric Immunoglobulin Receptor [NCIt concept]
- Single-Stranded DNA Cytosine Deaminase [NCIt concept]
- Stromal Cell-Derived Factor 1 [NCIt concept]
- T-Cell-Specific Surface Glycoprotein CD28 [NCIt concept]
- T-Lymphocyte Activation Antigen CD80 [NCIt concept]
- T-Lymphocyte Activation Antigen CD86 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 13 [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 13B [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 13B [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 13C [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 17 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 3 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 5 [NCIt concept]
pathway_has_gene_element
- AICDA wt Allele [NCIt concept]
- CCL25 wt Allele [NCIt concept]
- CCL28 wt Allele [NCIt concept]
- CCR10 wt Allele [NCIt concept]
- CCR9 wt Allele [NCIt concept]
- CD28 wt Allele [NCIt concept]
- CD40 wt Allele [NCIt concept]
- CD40LG wt Allele [NCIt concept]
- CD80 wt Allele [NCIt concept]
- CD86 wt Allele [NCIt concept]
- CXCL12 wt Allele [NCIt concept]
- CXCR4 wt Allele [NCIt concept]
- HLA-DMA wt Allele [NCIt concept]
- HLA-DMB wt Allele [NCIt concept]
- HLA-DOB wt Allele [NCIt concept]
- HLA-DQA1 wt Allele [NCIt concept]
- HLA-DQB1 wt Allele [NCIt concept]
- HLA-DRA wt Allele [NCIt concept]
- ICOS wt Allele [NCIt concept]
- ICOSLG wt Allele [NCIt concept]
- IL10 wt Allele [NCIt concept]
- IL15 wt Allele [NCIt concept]
- IL15RA wt Allele [NCIt concept]
- IL2 wt Allele [NCIt concept]
- IL4 wt Allele [NCIt concept]
- IL5 wt Allele [NCIt concept]
- IL6 wt Allele [NCIt concept]
- ITGA4 wt Allele [NCIt concept]
- ITGB7 wt Allele [NCIt concept]
- LTBR wt Allele [NCIt concept]
- MADCAM1 wt Allele [NCIt concept]
- MAP3K14 wt Allele [NCIt concept]
- PIGR wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]
- TNFRSF13B wt Allele [NCIt concept]
- TNFRSF13C wt Allele [NCIt concept]
- TNFRSF17 wt Allele [NCIt concept]
- TNFSF13 wt Allele [NCIt concept]
- TNFSF13B wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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