Integrin Alpha-4

Preferred Label : Integrin Alpha-4;

NCIt synonyms : ITGA4; Antigen CD49d; Integrin Alpha-IV; CD49d; VLA-4 Subunit Alpha; CD49 Antigen-Like Family Member D; CD49d Antigen;

NCIt definition : Integrin alpha-4 (1032 aa, 115 kDa) is encoded by the human ITGA4 gene. This protein is involved in the mediation of both cell-cell and cell-matrix interactions in leukocytes.;

Details

Origin ID

C97749;

UMLS CUI

C4721500;

Currated CISMeF NLP mapping
- Lymphocyte antigen CD49D (substance) [SNOMED CT concept]
- integrin alpha4 [MeSH Descriptor]
- integrin alpha4 [MeSH concept]
- lymphocyte antigen cd49d [SNOMED Notion]
OMIM relation
- Integrin, alpha-4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- Lymphocyte antigen CD49D (substance) [SNOMED CT concept]
- integrin alpha4 [MeSH concept]
- integrin alpha4 [MeSH Descriptor]
- lymphocyte antigen cd49d [SNOMED Notion]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cell Adhesion Molecule Gene [NCIt concept]
- ITGA4 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Adhesion Molecules on Lymphocyte Pathway [NCIt concept]
- Alpha4/Beta1 and Alpha4/Beta7 Integrin Signaling Pathway [NCIt concept]
- Arf6 Trafficking Pathway [NCIt concept]
- Arrhythmogenic Right Ventricular Cardiomyopathy Pathway [NCIt concept]
- Dilated Cardiomyopathy Pathway [NCIt concept]
- ECM-Receptor Interaction Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- Hypertrophic Cardiomyopathy Pathway [NCIt concept]
- Intestinal IgA Production Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- Local Acute Inflammatory Response Pathway [NCIt concept]
- Lymphocyte Adhesion Pathway [NCIt concept]
- Monocyte Phagocytosis and Adhesion Pathway [NCIt concept]
- Paxillin-Dependent Alpha4/Beta1 Integrin Signaling Pathway [NCIt concept]
- Paxillin-Independent Alpha4/Beta1 and Alpha4/Beta7 Integrin Signaling Pathway [NCIt concept]
- VEGFR3 Lymphatic Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- Integrin Alpha4/Beta1 [NCIt concept]
- Integrin Alpha4/Beta7 [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell-Cell Adhesion Process [NCIt concept]
- Cell-Matrix Adhesion Process [NCIt concept]
- Coagulation Process [NCIt concept]
- Heterodimerization [NCIt concept]
- Leukocyte Trafficking Induction [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Natalizumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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