Preferred Label : Monocyte Phagocytosis and Adhesion Pathway;
NCIt related terms : Monocyte and its Surface Molecules;
Alternative definition : BIOCARTA: Monocytes are a class of phagocytes involved in non-specific immune defense
that develop into macrophages. In plasma, monocytes ingest and destroy bacteria, and
can form macrophages when they enter the extracellular space in tissues. In addition
to the immune protection that monocytes provide, they may contribute to disease states
such as arthritis and heart disease through an aberrant immune response. As with other
immune cells, the immune function and differentiation of monocytes rely on communication
with other cells through cell surface proteins. Cell surface proteins are involved
in both interaction and adhesion with other cells and in transducing signals into
the cellular interior. The LFA-1 integrin (Leukocyte function-associated molecule
1) is composed of two subunits, CD11a and CD18 and is involved in monocytes adhesion
with ICAM-1 endothelial cells. Mac-1 is composed of the subunits CD11b and CD18 and
is induced during inflammation as well. PECAM-1 mediates the migration of monocytes
and other immune cells into inflamed tissues through interaction with vascular endothelial
cells. CD44 interaction of leukocytes with hyaluronan in the extracellular matrix
is induced by inflammation. VLA-4 is another integrin expressed on lymphocytes that
plays a role in adhesion through interaction with its adhesion partner on endothelial
cells, VCAM-1. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_monocytePathway;
Origin ID : C91307;
UMLS CUI : C2984148;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
