Natalizumab - CISMeF

Preferred Label : Natalizumab;

NCIt synonyms : Anti-alph4 Integrin Monoclonal Antibody AN100226; Anti-VLA4;

NCIt definition : A humanized recombinant IgG4 monoclonal antibody directed against the alpha4 subunit of the integrins alpha4beta1and alpha4beta7 with immunomodulating, anti-inflammatory, and potential antineoplastic activities. Natalizumab binds to the alpha4-subunit of alpha4beta1 and alpha4beta7 integrins expressed on the surface of all leukocytes except neutrophils, inhibiting the alpha4-mediated adhesion of leukocytes to counter-receptor(s) such as vascular cell adhesion molecule-1 (VCAM-1); natalizumab-mediated disruption of VCAM-1 binding by these integrins may prevent the transmigration of leukocytes across the endothelium into inflamed parenchymal tissue. Integrins are cellular adhesion molecules (CAMs) that are upregulated in various types of cancer and some autoimmune diseases; alpha4beta1 integrin (VLA4) has been implicated in the survival of myeloma cells, possibly by mediating their adhesion to stromal cells.;

UNII : 3JB47N2Q2P;

CAS number : 189261-10-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 189261-10-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Antegren; Tysabri;

Molecule name : AN100226;

Details

Origin ID

C77862;

UMLS CUI

C1172734;

Automatic exact mappings (from CISMeF team)
- Natalizumab [ICD-11 Extension code]
CISMeF manual mappings
- Natalizumab [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Natalizumab [MeSH Descriptor]
- Natalizumab [LOINC component]
- Natalizumab (substance) [SNOMED CT concept]
- Product containing natalizumab (medicinal product) [SNOMED CT concept]
- natalizumab [ATC Code]
- natalizumab [International Nonproprietary Name]
- natalizumab [MeSH concept]
Validated automatic mappings to BTNT
- natalizumab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Integrin Alpha-4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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