Local Acute Inflammatory Response Pathway

Preferred Label : Local Acute Inflammatory Response Pathway;

NCIt related terms : local acute inflammatory response;

Alternative definition : BIOCARTA: Inflammation has several distinct components, including the localized response at the site of tissue injury or infection. Tissue injury stimulates the release of inflammatory signaling molecules such as bradykinin. Bacterial infection stimulates an immune response in several ways. Bacteria that are phagocytosed can activate macrophages, causing the release of inflammatory cytokines such as IL-1, TNF, and IL-6. Bacteria can also activate the complement cascade through either the antibody-mediated pathway (classical pathway) or the alternative complement pathway. In extravascular tissues, cells that respond to infection or injury include macrophages and mast cells. Macrophages and other immune cells secrete chemokines that recruit leukocytes from the circulation to the site of inflammation. Mast cells release histamine, prostaglandins, and leukotrienes that act as chemokines, increase vascular permeability, and act on the vascular endothelium to increase tissue recruitment of leukocytes. Chemokines can recruit leukocytes or lymphocytes out of the blood stream into tissues and make blood vessels more permeable. Leukocytes are activated by inflammatory signals to express adhesion molecules that cause them to interact with the vascular endothelium, penetrate the endothelial wall and migrate into the extracellular space of tissues. The combined response of immune cells and signaling molecules at the site of inflammation induces swelling, activation of immune cells, and clearance of potential infectious agents. Chronic inflammation can however also lead to tissue damage in conditions such as arthritis, in which anti-inflammatory drugs act on various steps in inflammation to prevent disease. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_LairPathway;

Details

Origin ID

C39136;

UMLS CUI

C1517923;

Semantic type(s)
- Organ or Tissue Function [UMLS semantic type]
has_gene_product_element
- Bradykinin [NCIt concept]
- C3a Anaphylatoxin [NCIt concept]
- C5a Anaphylatoxin [NCIt concept]
- Complement C3 [NCIt concept]
- Complement C3 Beta Chain [NCIt concept]
- Complement C3d [NCIt concept]
- Complement C5 [NCIt concept]
- Integrin Alpha-4 [NCIt concept]
- Integrin Alpha-L [NCIt concept]
- Intercellular Adhesion Molecule 1 [NCIt concept]
- Interleukin-1 Alpha [NCIt concept]
- Interleukin-6 [NCIt concept]
- Interleukin-8 [NCIt concept]
- P-Selectin [NCIt concept]
- P-Selectin Glycoprotein Ligand 1 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Vascular Cell Adhesion Protein 1 [NCIt concept]
pathway_has_gene_element
- C3 wt Allele [NCIt concept]
- C5 wt Allele [NCIt concept]
- CXCL8 wt Allele [NCIt concept]
- ICAM1 wt Allele [NCIt concept]
- IL1A wt Allele [NCIt concept]
- IL6 wt Allele [NCIt concept]
- ITGA4 wt Allele [NCIt concept]
- ITGAL wt Allele [NCIt concept]
- KNG1 wt Allele [NCIt concept]
- SELP wt Allele [NCIt concept]
- SELPLG wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]
- VCAM1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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