Preferred Label : Complement C3;
NCIt synonyms : Complement Component 3; C3 and PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 1; Complement Component-3;
NCIt related terms : C3;
NCIt definition : Complement C3 (1663 aa, 187 kDa) is encoded by the human C3 gene. This protein plays
a role in complement-mediated immunity.;
Alternative definition : NICHD: The component of the early complement cascade common to all three activation
pathways. C3 is consumed by proteolysis upon activation. C3 levels are generally low
when immune complex mediated diseases are active, such as systemic lupus erythematosus
or post-streptococcal glomerulonephritis.;
NCIt note : Complement C3 is cleaved into the following 10 chains: Complement C3 beta chain, Complement
C3 alpha chain, C3a anaphylatoxin, Complement C3b alpha' chain, Complement C3c alpha'
chain fragment 1, Complement C3dg fragment, Complement C3g fragment, Complement C3d
fragment, Complement C3f fragment, and Complement C3c alpha' chain fragment 2. (UniProt); Complement Component 3, encoded by the C3 gene plays a central role in the activation
of complement system. Its activation is required for both classical and alternative
complement activation pathways. People with C3 deficiency are susceptible to bacteria
infection. (From LocusLink);
Origin ID : C21527;
UMLS CUI : C1571455;
Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_biochemical_function
- gene_product_has_organism_source
- gene_product_is_element_in_pathway
- gene_product_malfunction_associated_with_disease
- gene_product_plays_role_in_biological_process
- is_target
