complement C3 - CISMeF

Preferred Label : complement C3;

MeSH definition : A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.;

MeSH synonym : c3 complement; complement component 3; component 3, complement; c3, complement; complement 3; complement, C3;

MeSH Hyperonym : complement C3 precursor; C3 Precursor, Complement; Precursor, Complement C3; Pro-C3; Pro C3; Precursor-Complement 3; Precursor Complement 3; Pro-Complement 3; Pro Complement 3; C3 Precursor; Precursor, C3;

Is substance : O;

Details

Origin ID

D003176;

UMLS CUI

C0009506;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Complement C3 [LOINC component]
- Complement C3 [NCIt concept]
Pharmacological action(s)
- immunologic factors [MeSH Descriptor]
Record concept(s)
- complement C3 [MeSH concept]
- complement C3 precursor [MeSH concept]
Related MeSH Supplementary Concept(s)
- C3 protein, human [MeSH Supplementary Concept]
- C3 protein, mouse [MeSH Supplementary Concept]
- CPAMD8 protein, human [MeSH Supplementary Concept]
- complement component 3 deficiency, autosomal recessive [MeSH Supplementary Concept]
- complement factor I deficiency [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- C3(H20) (substance) [SNOMED CT concept]
- Complement C3 [LOINC component]
- Complement component C3 (substance) [SNOMED CT concept]
- c3(h20) [SNOMED Notion]
- complement component c3, nos [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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