C3a Anaphylatoxin

Preferred Label : C3a Anaphylatoxin;

NCIt synonyms : Anaphylatoxin C3a; Complement C3a Anaphylatoxin;

NCIt definition : C3a anaphylatoxin (77 aa, 9 kDa) is encoded by the human C3 gene. This protein is involved in T-cell activation and survival, promotion of angiogenesis, chemotaxis, mast cell degranulation, macrophage activation and binding to complement component 3a receptor 1 (C3AR1).;

NCIt note : C3a is rapidly cleaved by either carboxypeptidase B or N, which remove the carboxyl-terminal arginine to generate acylation stimulating protein (ASP or C3adesArg).; C3a anaphylatoxin is comprised of amino acids 672-748 of complement C3 and is produced through proteolysis of complement C3 into a C-terminal alpha chain and a N-terminal beta chain followed by further proteolysis of the complement C3 alpha chain. (UniProt);

NCI Metathesaurus CUI : CL1770630;

Details

Origin ID

C182131;

UMLS CUI

C1569736;

Automatic exact mappings (from CISMeF team)
- complement C3 [ORDO Gene]
- complement C3 [HGNC gene]
OMIM relation
- Complement component 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- C3a anaphylatoxin, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- C3 Gene [NCIt concept]
- Complement Component Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
gene_product_has_associated_anatomy
- Central Nervous System [NCIt concept]
- Epithelial Cell [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Complement [NCIt concept]
- Protein Fragment [NCIt concept]
gene_product_is_element_in_pathway
- Alternative Complement Pathway [NCIt concept]
- Classical Complement Pathway [NCIt concept]
- Complement Pathway [NCIt concept]
- Lectin Induced Complement Pathway [NCIt concept]
- Local Acute Inflammatory Response Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Chemotactic Process [NCIt concept]
- Complement Activation [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Host Defense Mechanism [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Maturation [NCIt concept]

Keyword's position in hierarchy(ies) :

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