Complement C3 Beta Chain

Preferred Label : Complement C3 Beta Chain;

NCIt synonyms : C3b; Complement Component C3b; Complement C3b;

NCIt definition : Complement C3 beta chain (645 aa, 71 kDa) is encoded by the human C3 gene. This protein is involved in binding to microbial surfaces, attachment to Fc regions of antigen-bound antibodies, opsonization, phagocytosis and complement activation. Uncontrolled generation of this protein fragment is associated with C3 glomerulopathy and atypical hemolytic uremic syndrome (aHUS).;

NCIt note : Complement C3 beta chain (C3b) is comprised of amino acids 23-667 of complement C3 and is produced through proteolysis of complement C3 into a C-terminal alpha chain and a N-terminal beta chain (C3b). C3b can bind to complement factor B to form C3 convertase. When C3b bind to C4b and C2b (C4b2b3b complex) or when a second C3b molecule binds to the C3bBb complex (C3bBb3b complex) the C5 convertase is formed.;

NCI Metathesaurus CUI : CL1771130;

Details

Origin ID

C182443;

UMLS CUI

C5575716;

Automatic exact mappings (from CISMeF team)
- Complement C3b [LOINC component]
- Complement component C3b (substance) [SNOMED CT concept]
- complement C3 [ORDO Gene]
- complement C3 [HGNC gene]
- complement C3b [MeSH Descriptor]
- complement C3b [MeSH concept]
- complement component c3b [SNOMED Notion]
OMIM relation
- Complement component 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- C3 Gene [NCIt concept]
- Complement Component Gene [NCIt concept]
gene_product_has_biochemical_function
- Complement [NCIt concept]
- Protein Fragment [NCIt concept]
gene_product_is_element_in_pathway
- Alternative Complement Pathway [NCIt concept]
- Classical Complement Pathway [NCIt concept]
- Complement Pathway [NCIt concept]
- Lectin Induced Complement Pathway [NCIt concept]
- Local Acute Inflammatory Response Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Complement Activation [NCIt concept]
- Host Defense Mechanism [NCIt concept]
- Proteolytic Processing [NCIt concept]

Keyword's position in hierarchy(ies) :

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